RapamycinFungusV1, Main, Exploration, bibRecord, 001A45

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast.

Identifieur interne : 001A45 ( Main/Exploration ); précédent : 001A44; suivant : 001A46

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast.

Auteurs : Y. Jiang [États-Unis] ; J R Broach

Source :

The EMBO journal [ 0261-4189 ] ; 1999.

RBID : pubmed:10329624

Descripteurs français

KwdFr :
- Liaison aux protéines (MeSH), Mutation (MeSH), Phosphoprotein Phosphatases (génétique), Phosphoprotein Phosphatases (métabolisme), Phosphorylation (MeSH), Protein Phosphatase 2 (MeSH), Protéines adaptatrices de la transduction du signal (MeSH), Protéines de Drosophila (MeSH), Protéines de Saccharomyces cerevisiae (MeSH), Protéines de liaison à l'ARN (métabolisme), Protéines du cycle cellulaire (métabolisme), Protéines fongiques (métabolisme), Récepteurs à activité tyrosine kinase (génétique), Récepteurs à activité tyrosine kinase (métabolisme), Régulation de l'expression des gènes fongiques (MeSH), Résistance aux substances (MeSH), Saccharomyces cerevisiae (croissance et développement), Saccharomyces cerevisiae (génétique), Saccharomyces cerevisiae (métabolisme), Sirolimus (pharmacologie), Transduction du signal (MeSH).
MESH :
- croissance et développement : Saccharomyces cerevisiae.
- génétique : Phosphoprotein Phosphatases, Récepteurs à activité tyrosine kinase, Saccharomyces cerevisiae.
- métabolisme : Phosphoprotein Phosphatases, Protéines de liaison à l'ARN, Protéines du cycle cellulaire, Protéines fongiques, Récepteurs à activité tyrosine kinase, Saccharomyces cerevisiae.
- pharmacologie : Sirolimus.
- Liaison aux protéines, Mutation, Phosphorylation, Protein Phosphatase 2, Protéines adaptatrices de la transduction du signal, Protéines de Drosophila, Protéines de Saccharomyces cerevisiae, Régulation de l'expression des gènes fongiques, Résistance aux substances, Transduction du signal.

English descriptors

KwdEn :
- Adaptor Proteins, Signal Transducing (MeSH), Cell Cycle Proteins (metabolism), Drosophila Proteins (MeSH), Drug Resistance (MeSH), Fungal Proteins (metabolism), Gene Expression Regulation, Fungal (MeSH), Mutation (MeSH), Phosphoprotein Phosphatases (genetics), Phosphoprotein Phosphatases (metabolism), Phosphorylation (MeSH), Protein Binding (MeSH), Protein Phosphatase 2 (MeSH), RNA-Binding Proteins (metabolism), Receptor Protein-Tyrosine Kinases (genetics), Receptor Protein-Tyrosine Kinases (metabolism), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (growth & development), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (MeSH), Signal Transduction (MeSH), Sirolimus (pharmacology).
MESH :
- chemical , genetics : Phosphoprotein Phosphatases, Receptor Protein-Tyrosine Kinases.
- chemical , metabolism : Cell Cycle Proteins, Fungal Proteins, Phosphoprotein Phosphatases, RNA-Binding Proteins, Receptor Protein-Tyrosine Kinases.
- chemical , pharmacology : Sirolimus.
- chemical : Adaptor Proteins, Signal Transducing, Drosophila Proteins, Protein Phosphatase 2, Saccharomyces cerevisiae Proteins.
- genetics : Saccharomyces cerevisiae.
- growth & development : Saccharomyces cerevisiae.
- metabolism : Saccharomyces cerevisiae.
- Drug Resistance, Gene Expression Regulation, Fungal, Mutation, Phosphorylation, Protein Binding, Signal Transduction.

Abstract

Tor proteins, homologous to DNA-dependent protein kinases, participate in a signal transduction pathway in yeast that regulates protein synthesis and cell wall expansion in response to nutrient availability. The anti-inflammatory drug rapamycin inhibits yeast cell growth by inhibiting Tor protein signaling. This leads to diminished association of a protein, Tap42, with two different protein phosphatase catalytic subunits; one encoded redundantly by PPH21 and PPH22, and one encoded by SIT4. We show that inactivation of either Cdc55 or Tpd3, which regulate Pph21/22 activity, results in rapamycin resistance and that this resistance correlates with an increased association of Tap42 with Pph21/22. Furthermore, we show Tor-dependent phosphorylation of Tap42 both in vivo and in vitro and that this phosphorylation is rapamycin sensitive. Inactivation of Cdc55 or Tpd3 enhances in vivo phosphorylation of Tap42. We conclude that Tor phosphorylates Tap42 and that phosphorylated Tap42 effectively competes with Cdc55/Tpd3 for binding to the phosphatase 2A catalytic subunit. Furthermore, Cdc55 and Tpd3 promote dephosphorylation of Tap42. Thus, Tor stimulates growth-promoting association of Tap42 with Pph21/22 and Sit4, while Cdc55 and Tpd3 inhibit this association both by direct competition and by dephosphorylation of Tap42. These results establish Tap42 as a target of Tor and add further refinement to the Tor signaling pathway.

DOI: 10.1093/emboj/18.10.2782
PubMed: 10329624
PubMed Central: PMC1171359

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Tor proteins, homologous to DNA-dependent protein kinases, participate in a signal transduction pathway in yeast that regulates protein synthesis and cell wall expansion in response to nutrient availability. The anti-inflammatory drug rapamycin inhibits yeast cell growth by inhibiting Tor protein signaling. This leads to diminished association of a protein, Tap42, with two different protein phosphatase catalytic subunits; one encoded redundantly by PPH21 and PPH22, and one encoded by SIT4. We show that inactivation of either Cdc55 or Tpd3, which regulate Pph21/22 activity, results in rapamycin resistance and that this resistance correlates with an increased association of Tap42 with Pph21/22. Furthermore, we show Tor-dependent phosphorylation of Tap42 both in vivo and in vitro and that this phosphorylation is rapamycin sensitive. Inactivation of Cdc55 or Tpd3 enhances in vivo phosphorylation of Tap42. We conclude that Tor phosphorylates Tap42 and that phosphorylated Tap42 effectively competes with Cdc55/Tpd3 for binding to the phosphatase 2A catalytic subunit. Furthermore, Cdc55 and Tpd3 promote dephosphorylation of Tap42. Thus, Tor stimulates growth-promoting association of Tap42 with Pph21/22 and Sit4, while Cdc55 and Tpd3 inhibit this association both by direct competition and by dephosphorylation of Tap42. These results establish Tap42 as a target of Tor and add further refinement to the Tor signaling pathway.</div>
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<Abstract><AbstractText>Tor proteins, homologous to DNA-dependent protein kinases, participate in a signal transduction pathway in yeast that regulates protein synthesis and cell wall expansion in response to nutrient availability. The anti-inflammatory drug rapamycin inhibits yeast cell growth by inhibiting Tor protein signaling. This leads to diminished association of a protein, Tap42, with two different protein phosphatase catalytic subunits; one encoded redundantly by PPH21 and PPH22, and one encoded by SIT4. We show that inactivation of either Cdc55 or Tpd3, which regulate Pph21/22 activity, results in rapamycin resistance and that this resistance correlates with an increased association of Tap42 with Pph21/22. Furthermore, we show Tor-dependent phosphorylation of Tap42 both in vivo and in vitro and that this phosphorylation is rapamycin sensitive. Inactivation of Cdc55 or Tpd3 enhances in vivo phosphorylation of Tap42. We conclude that Tor phosphorylates Tap42 and that phosphorylated Tap42 effectively competes with Cdc55/Tpd3 for binding to the phosphatase 2A catalytic subunit. Furthermore, Cdc55 and Tpd3 promote dephosphorylation of Tap42. Thus, Tor stimulates growth-promoting association of Tap42 with Pph21/22 and Sit4, while Cdc55 and Tpd3 inhibit this association both by direct competition and by dephosphorylation of Tap42. These results establish Tap42 as a target of Tor and add further refinement to the Tor signaling pathway.</AbstractText>
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	Serveur d'exploration sur la rapamycine et les champignons
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Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast.

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast.

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